> The Holiday Inn Express Hotel & Suites in O'Fallon, MO is located just west of St. Louis. Our hotel is convenient to Interstate 64 and is near several local attractions and businesses making it the perfect hotel for travelers looking for lodging in O'Fallon. Conveniently located near major companies such as Citi Corporation, General Motors, Mastercard, APC, Nortek, the Missouri Research Park and Progress West Hospital, our O'Fallon, MO hotel is ideal for both Business and Leisure travelers. We are just minutes from historic St. Charles, Six Flags Over St. Louis and the Augusta vineyards. The St. Louis Arch, Anheuser-Busch, Laclede's Landing and the stadiums of the Cardinals and the Blues are just a short drive into St. Louis from our hotel in O'Fallon. During your stay at our pet friendly O'Fallon, Missouri hotel be sure to take advantage of our choice amenities, including a heated, indoor pool, fitness center and the free Express Start hot breakfast bar featuring our signature cinnamon rolls. Check out our great O'Fallon hotel deals and book your stay today.