Methodist preaching in Jackson dates back to the early 1800's, when it was part of the Natchez and Wilkinson circuits. It was put on the Feliciana circuit in 1827, and then on the Jackson circuit in 1851. It was a part of the Mississippi Conference until 1894.

On January 10, 1854, Centenary College donated a tract of land, one block from the college, to the church. A new church was built under the leadership of Rev. A.T.M. Fly. It was dedicated on March 4, 1855 when the Mississippi Annual Conference was held at the church. The church, built at a cost of $9000, was pastored at that time by Rev. Almerin G. Miller. Documentation for an earlier church is lacking, though there is a document that notes the Baptists bought a lot from the Methodists. This lot is located at the old post office site.

The original church bell was donated to the Confederacy during the Civil War and melted down for bullets. The present bell comes from plantation owner Stephen E. Beauchamp, who donated it to the church after the war.
Renovations were done on the church in 1952-1953. Additional structures were added in 1958-1959. In the mid 1980's, an education building was constructed. The consecration service was held March 24, 1985. A new parsonage, on the same block as the church, was built in 2002.
The church is listed on the National Register of Historic Places and was designated a Historic Site by the Louisiana Conference.